Edward Lifesciences is an American medical technology company headquartered in Irvine, California, specializing in artificial heart valves and hemodynamic monitoring. It developed the SAPIEN transcatheter aortic heart valve made of cow tissue within a balloon-expandable, cobalt-chromium frame, deployed via a catheter. It operates major manufacturing facilities at multiple locations in the U.S., as well as in the Dominican Republic, Costa Rica, Singapore, Puerto Rico and Ireland.